Design and Manufacture Of A Tick Collecting Robot

The overall goal of this research project is to fully design, manufacture, and test a robot for tick collection. The robot will be designed to collect ticks in regions with thickly branched vegetation, specifically including shrubs, trees, and leaf liter. The robot will be useful to biologists who collect ticks for research or disease control purposes, because it will reach areas that are inaccessible to human-powered collection methods and thus provide them with a more accurate estimate of the tick density in a given region. Obtaining a more precise tick density is crucial, because it provides more detailed information about certain regions and the likelihood of encountering a tick species that transmits a harmful disease. The robot design incorporates several features that will enable it to succeed in tick collection. The small compact size of the robot will allow the robot to maneuver in between obstacles such as branches and trees in the environment. The primary method of collection that will be implemented is dragging. The environment that the robot is designed to navigate is the Albany Pine Bush, which contains an uneven terrain mainly consisting of dirt, shrubs, and leaf liter, and the robot chassis is designed for this environment

Conceptual Analysis of Black Hole Entropy in String Theory

The microscopic state counting of the extremal Reissner-Nordstr\"om black hole performed by Andrew Strominger and Cumrun Vafa in 1996 has proven to be a central result in string theory. Here, with a philosophical readership in mind, the argument is presented in its contemporary context and its rather complex conceptual structure is analysed. In particular, we will identify the various inter-theoretic relations, such as duality and linkage relations, on which it depends. We further aim to make clear why the argument was immediately recognised as a successful accounting for the entropy of this black hole and how it engendered subsequent work that intended to strengthen the string theoretic analysis of black holes. Its relation to the formulation of the AdS/CFT conjecture will be briefly discussed, and the familiar reinterpretation of the entropy calculation in the context of the AdS/CFT correspondence is given. Finally, we discuss the heuristic role that Strominger and Vafa's microscopic account of black hole entropy played for the black hole information paradox. A companion paper analyses the ontology of the Strominger-Vafa black hole states, the question of emergence of the black hole from a collection of D-branes, and the role of the correspondence principle in the context of string theory black holes.Comment: 70 page

Emergence and Correspondence for String Theory Black Holes

This is one of a pair of papers that give a historical-\emph{cum}-philosophical analysis of the endeavour to understand black hole entropy as a statistical mechanical entropy obtained by counting string-theoretic microstates. Both papers focus on Andrew Strominger and Cumrun Vafa's ground-breaking 1996 calculation, which analysed the black hole in terms of D-branes. The first paper gives a conceptual analysis of the Strominger-Vafa argument, and of several research efforts that it engendered. In this paper, we assess whether the black hole should be considered as emergent from the D-brane system, particularly in light of the role that duality plays in the argument. We further identify uses of the quantum-to-classical correspondence principle in string theory discussions of black holes, and compare these to the heuristics of earlier efforts in theory construction, in particular those of the old quantum theory.Comment: 40 page

Emergence and Correspondence for String Theory Black Holes

This is one of a pair of papers that give a historical-cum-philosophical analysis of the endeavour to understand black hole entropy as a statistical mechanical entropy obtained by counting string-theoretic microstates. Both papers focus on Andrew Strominger and Cumrun Vafa's ground-breaking 1996 calculation, which analysed the black hole in terms of D-branes. The first paper gives a conceptual analysis of the Strominger-Vafa argument, and of several research efforts that it engendered. In this paper, we assess whether the black hole should be considered as emergent from the D-brane system, particularly in light of the role that duality plays in the argument. We further identify uses of the quantum-to-classical correspondence principle in string theory discussions of black holes, and compare these to the heuristics of earlier efforts in theory construction, in particular those of the old quantum theory

Conceptual Analysis of Black Hole Entropy in String Theory

The microscopic state counting of the extremal Reissner-Nordstr\"om black hole performed by Andrew Strominger and Cumrun Vafa in 1996 has proven to be a central result in string theory. Here, with a philosophical readership in mind, the argument is presented in its contemporary context and its rather complex conceptual structure is analysed. In particular, we will identify the various inter-theoretic relations, such as duality and linkage relations, on which it depends. We further aim to make clear why the argument was immediately recognised as a successful accounting for the entropy of this black hole and how it engendered subsequent work that intended to strengthen the string theoretic analysis of black holes. Its relation to the formulation of the AdS/CFT conjecture will be briefly discussed, and the familiar reinterpretation of the entropy calculation in the context of the AdS/CFT correspondence is given. Finally, we discuss the heuristic role that Strominger and Vafa's microscopic account of black hole entropy played for the black hole information paradox. A companion paper analyses the ontology of the Strominger-Vafa black hole states, the question of emergence of the black hole from a collection of D-branes, and the role of the correspondence principle in the context of string theory black holes

Conceptual Analysis of Black Hole Entropy in String Theory

The microscopic state counting of the extremal Reissner-Nordström black hole performed by Andrew Strominger and Cumrun Vafa in 1996 has proven to be a central result in string theory. Here, with a philosophical readership in mind, the argument is presented in its contemporary context and its rather complex conceptual structure is analysed. In particular, we will identify the various inter-theoretic relations, such as duality and linkage relations, on which it depends. We further aim to make clear why the argument was immediately recognised as a successful accounting for the entropy of this black hole and how it engendered subsequent work that intended to strengthen the string theoretic analysis of black holes. Its relation to the formulation of the AdS/CFT conjecture will be briefly discussed, and the familiar reinterpretation of the entropy calculation in the context of the AdS/CFT correspondence is given. Finally, we discuss the heuristic role that Strominger and Vafa's microscopic account of black hole entropy played for the black hole information paradox. A companion paper analyses the ontology of the Strominger-Vafa black hole states, the question of emergence of the black hole from a collection of D-branes, and the role of the correspondence principle in the context of string theory black holes

Conceptual Analysis of Black Hole Entropy in String Theory

The microscopic state counting of the extremal Reissner-Nordstr\"om black hole performed by Andrew Strominger and Cumrun Vafa in 1996 has proven to be a central result in string theory. Here, with a philosophical readership in mind, the argument is presented in its contemporary context and its rather complex conceptual structure is analysed. In particular, we will identify the various inter-theoretic relations, such as duality and linkage relations, on which it depends. We further aim to make clear why the argument was immediately recognised as a successful accounting for the entropy of this black hole and how it engendered subsequent work that intended to strengthen the string theoretic analysis of black holes. Its relation to the formulation of the AdS/CFT conjecture will be briefly discussed, and the familiar reinterpretation of the entropy calculation in the context of the AdS/CFT correspondence is given. Finally, we discuss the heuristic role that Strominger and Vafa's microscopic account of black hole entropy played for the black hole information paradox. A companion paper analyses the ontology of the Strominger-Vafa black hole states, the question of emergence of the black hole from a collection of D-branes, and the role of the correspondence principle in the context of string theory black holes

Scopoletin 8-hydroxylase: a novel enzyme involved in coumarin biosynthesis and iron-deficiency responses in Arabidopsis: A novel enzyme involved in coumarin biosynthesis and iron-deficiency responses in Arabidopsis

International audienceIron deficiency is a serious agricultural problem, particularly in alkaline soils. Secretion of coumarins by Arabidopsis thaliana roots is induced under iron deficiency. An essential enzyme for the biosynthesis of the major Arabidopsis coumarins, scopoletin and its derivatives, is Feruloyl-CoA 6′-Hydroxylase1 (F6′H1), which belongs to a large enzyme family of the 2-oxoglutarate and Fe2+-dependent dioxygenases. We have functionally characterized another enzyme of this family, which is a close homologue of F6′H1 and is encoded by a strongly iron-responsive gene, At3g12900. We purified At3g12900 protein heterologously expressed in Escherichia coli and demonstrated that it is involved in the conversion of scopoletin into fraxetin, via hydroxylation at the C8 position, and that it thus functions as a scopoletin 8-hydroxylase (S8H). Its function in plant cells was confirmed by the transient expression of S8H protein in Nicotiana benthamiana leaves, followed by metabolite profiling and biochemical and ionomic characterization of Arabidopsis s8h knockout lines grown under various iron regimes. Our results indicate that S8H is involved in coumarin biosynthesis, as part of mechanisms used by plants to assimilate iron

Codesigning a patient support portal with health professionals and men with prostate cancer: An action research study

Abstract Introduction The supportive care needs of men with prostate cancer (PCa) have been well documented, but little is known about how an online portal may address these. This study sought to determine priority issues facing men with PCa, barriers and enablers to accessing care and whether health professionals (HPs) and men would support the inclusion of a patient‐reported outcome (PRO) comparator tool. Methods We conducted four online focus groups with HPs recruited from healthcare services in Victoria, followed by seven online codesign workshops with men with PCa, recruited through the Victorian Prostate Cancer Outcomes Registry, Prostate Cancer Foundation Australia and the Cancer Council Victoria. Men were eligible to participate if they had lived experience of PCa and access to the internet. We analysed focus groups thematically. Workshops were analysed using descriptive‐content analysis. Results HPs (n = 39) highlighted that men had shifting priorities over time, but noted the importance of providing information to men in lay terms to assist in treatment decision‐making and side‐effect management. HPs identified key enablers to men accessing support services such as practice nurses, partners and having men share their stories with each other. HPs raised financial, cultural, geographic and emotional barriers to accessing supportive care. Inclusion of a PRO comparator tool received mixed support from HPs, with 41% (n = 16) supportive, 49% (n = 19) unsure and 10% (n = 4) not supportive. Men involved in workshops (n = 28) identified informational needs to assist in treatment decision‐making and side‐effect management as the top priority throughout care. Men described support groups and practice nurses as key enablers. Short consultation times and complex information were described as barriers. Unlike HPs, all men supported the inclusion of a PRO comparator tool in a portal. Conclusions Our findings suggest that a patient support portal should provide information in lay terms that address the shifting priorities of men with PCa. Men with PCa would welcome the development of a portal to centralize support information and a PRO comparator tool to prompt health‐seeking behaviour. Future research will implement these findings in the development of a portal, and pilot and evaluate the portal within a population‐based sample. Patient or Public Contribution This project adopted a codesign approach including both men with PCa and HPs involved in PCa care. Men with PCa also formed part of the study's steering committee and consumer advisory groups. HPs were consulted in a serious of online focus groups. Subsequently, men with PCa and their support persons participated in workshops. Men with PCa were also involved in the preparation of this manuscript